What the heck

There are so many synergy combinations now that I've read through guides and I'm completely lost. Are 'Disappearing Life' and 'Ruin' outdated now? Burn, Remnant Peak, Amadant, Wind Erosion, Umbra Core, Magic Crit, Terror, Attack Speed Isn't Burn the most busted one? If the ultimate skill 'Seclusion' doesn't kill you even when eaten by Yo, isn't it just a free-for-all of Yo's 3000%? I pulled on banners based on my preferences, so every synergy combination is just one person short. I guess games really aren't just for fun.